Hot flashes, mood swings—menopause is nothing if not frustrating. For many women, weight gain is one of the worst parts. Extra pounds will suddenly appear and no amount of diet or exercise seems to help.

Sound familiar? You’re not alone, and more importantly, you’re not doing anything wrong. Your hormones have shifted, and your body needs new tools. That’s where GLP-1s come in. These powerful medications are helping more women over 40 take back control of their weight, energy, and overall health.

GLP-1s work by curbing appetite, reducing cravings, and improving how your body uses insulin—key factors that often get disrupted during menopause. By regulating blood sugar and helping your metabolism run more efficiently, they support steady, sustainable weight loss without extreme dieting or burnout.

GLP-1s for Menopause Weight Gain

GLP-1 medications can help you lose weight without the need for crash dieting by curbing appetite and reducing cravings, making it easier to eat less naturally without feeling deprived. They also improve insulin sensitivity, which is especially important for women in menopause who may experience insulin resistance—this helps regulate blood sugar and can lower the risk of developing type 2 diabetes.

Unlike quick fixes that only address surface-level symptoms, GLP-1s work with your hormones and target one of the root causes of menopause-related weight gain: the metabolic slowdown caused by hormonal changes. Most importantly, GLP-1s support long-term change and are part of a science-backed, sustainable approach to weight loss for women over 40.

GLP-1s Manages Menopause Symptoms & More

From improving metabolism and reducing stubborn weight gain to stabilizing blood sugar and curbing appetite, GLP-1 medications help women over 40 feel more in control of their health. Combined with healthy habits and expert guidance, GLP-1s can be a powerful tool to navigate menopause.


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Health Benefits of GLP-1s for Women

Beyond weight loss, GLP-1s have been shown to support:

• Cardiovascular health

• Improved blood sugar regulation

• Lower blood pressure

• Better cholesterol levels

These benefits are particularly valuable during and after menopause—when the risk of chronic conditions like diabetes and heart disease increases.

Additional Benefits of GLP-1s  for Menopause

Most women start seeing results within the first 4–8 weeks. These may include:

• Steady, consistent weight loss

• Reduced appetite and fewer cravings

• More energy and mental clarity

• Improved sleep and mood

Of course, every journey is different, but when combined with lifestyle support and coaching, GLP-1s can help you feel better, stronger, and more in control.

Menopause Symptoms

Let’s start with the basics. Menopause marks the end of your reproductive years and comes with a natural decline in estrogen, progesterone, and other key hormones. This hormonal shift can lead to:

• Slowed metabolism

• Increased belly fat

• Sleep disturbances

• Mood changes and fatigue

• Insulin resistence

And all of that makes it much harder to lose weight—even if you're doing all the “right” things.

Why Diet and Exercise Aren’t Always Enough

You’ve probably heard that all it takes is "calories in vs. calories out"—but menopause changes the rules. Hormonal shifts slow your metabolism, increase fat storage (especially around your belly), and make your body less responsive to the diet and exercise routines that once worked. Plus, menopause can impact:

• Muscle Mass - Loss of lean muscle lowers your metabolic rate

• Energy Levels - You may feel too fatigued to work out

• Sleep Quality - Poor sleep increases cravings

• Stress Levels - Higher cortisol levels lead to increased fat storage

Menopause Weight Gain? It's not your fault.

Your body’s biology has changed, and it’s not something you can fix with willpower alone. What worked in the past may no longer deliver the same results. With the right support, you can feel like yourself again!


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Emotional Side of Menopause Weight Gain

Let’s be honest: the weight is only part of it. What really hurts is how invisible it can make you feel. How hard it is to look in the mirror and not recognize the person staring back. The frustration of doing everything "right" and still feeling like your body is working against you can take a serious toll—not just physically, but emotionally.

GLP-1s aren’t a vanity fix—they’re a path back to feeling like yourself. To waking up with more energy, moving with more ease, and showing up for your life with renewed confidence. For many women, it's not just about dropping pounds—it’s about lifting the mental weight of shame, fatigue, and self-doubt that’s been quietly building for years.

Because feeling like yourself again isn’t shallow. It’s powerful. And it’s absolutely worth investing in.

“Menopause brings a complex set of changes—physically and emotionally. While GLP-1s aren’t a cure-all, they can be a valuable part of a broader treatment plan. Especially when weight and metabolic health become more difficult to manage." – Dr. Weiss Surkhabi, Chief Medical Officer of Fridays Health

GLP-1s and the Future of Women’s Health

GLP-1 medications are more than a trending treatment—they’re part of a larger shift in how midlife women’s health is finally being recognized, studied, and supported. For too long, the physical, emotional, and metabolic changes of menopause were treated as an afterthought, or worse—dismissed as something women simply had to “push through.”

That’s changing. Research is increasingly showing that menopause-related weight gain is tied to real, measurable changes in metabolism, insulin sensitivity, and appetite signaling. And GLP-1s offer a powerful, science-backed way to address those challenges head-on.

But it’s not just about the medication. It’s about access, understanding, and support—the kind of comprehensive care that takes women seriously and meets them where they are. Fridays is proud to be part of that future.

We’re helping rewrite the story of midlife health by:

✔ Centering care around women’s unique needs during and after menopause

✔ Offering judgment-free support and clinically backed treatment plans

✔ Combining medication with coaching, community, and emotional care

✔ Empowering women to take control of their health on their own terms

You’re not invisible. You’re not stuck.GLP-1s are opening the door to better options—and Fridays is walking through that door with you, step by step.

We know starting something new can be overwhelming—especially if you’ve already tried everything. That’s why we built Fridays to be as supportive as it is effective.

Here’s what makes us different:

Microdosing Options - Start small. Build tolerance. See results without the rough start.

Patient Support - We pair you with providers and coaches who understand the unique needs of women in menopause.

Everything Online - No office visits. No wasted time. Just expert care delivered to your door.

Holistic  Approach - Our coaching covers mental health, nutrition, movement, and habit-building so we've got you covered.

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Frequently Asked Questions

Are GLP-1s Safe for Women Over 40?

Yes, GLP-1s are FDA-approved and when prescribed by a medical provider and taken as directed, they’re safe and effective for most people. Fridays’ plans are always tailored to your unique needs and health history.‍



Will GLP-1s Affect My Hormones?

GLP-1s don’t directly change your hormone levels, but they help reduce the impact of hormonal weight gain by supporting metabolism and appetite control.‍


Will I Have to Stay On GLP-1s Forever?

Not necessarily. Many women use GLP-1s to jumpstart progress, build momentum, and eventually transition to maintenance plans. Our team helps guide you every step of the way.‍



What Are Common GLP-1 Side Effects?

Some women experience mild nausea, fatigue, or changes in appetite when starting GLP-1s. Fridays offers microdosed options and personalized guidance to help minimize side effects.




About the Author

Dr. Weiss Surkhabi, MD, is a double board-certified physician in Family Medicine and Obesity Medicine. As Chief Medical Officer at Fridays, he is dedicated to providing compassionate care and empowering individuals with the tools and support they need to improve their health and well-being. Dr. Surkhabi is passionate about addressing disparities in healthcare and helping people live healthier, more fulfilling lives.