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Daily oral pill

Ozempic (generic name: Semaglutide) is a GLP-1 agonist FDA approved for the treatment of type 2 diabetes.

Bupropion (brand name: Wellbutrin, Aplenzin, Zyban or Forfivo) is FDA approved as an antidepressant and for smoking cessation. However, its off-label use has shown effectiveness with weight loss.

How does



  • acts on receptors and neurotransmitters in the brain that may reduce appetite and cravings 

Common side effects of


  • dry mouth
  • hyperventilation
  • irregular heartbeats
  • anxiety
  • shaking
  • irritability
  • trouble sleeping
  • headache
  • ringing in ears

Expected Results: 

  • Individuals on bupropion lost between 7 to 10% of their body weight, depending on the dosage.

Do not take


if you:

  • have a history of seizures
  • abruptly discontinued taking alcohol, benzodiazepines, barbiturates or anti-epileptic drugs 
  • are taking linezolid or methylene blue
  • have a current or prior diagnosis of anorexia or bulimia 
  • are taking a monoamine oxidase inhibitor (MAOIs)
  • are allergic to bupropion or any of its ingredients

Disclaimer: Please note that the following list may not encompass all potential side effects or drug interactions. To determine if any drug or supplement you are currently taking could interact with a medication, we strongly advise consulting your healthcare provider or pharmacist. Seek medical advice immediately if you experience any adverse reaction.